Preheat oven to 400 degrees.
Combine Panko bread crumbs, melted butter and 1/4 cup parmesan cheese. Set aside.
Cook macaroni al dente according to package directions. Drain and run under cold water.
Whisk in milk, cream and seasonings over medium heat. Continue to stir until mixture thickens. Let boil 1 minute while stirring.
Remove from heat and add cheddar cheese, gruyere cheese and remaining 1/2 cup parmesan cheese. Whisk until melted.
Top with crumb mixture and bake 20-25 minutes or until bubbly and topping is browned. Do not overcook.
(Nutrition information provided is an estimate and will vary based on cooking methods and brands of ingredients used.)